Biomedical Advances

How keyhole heart-valve procedures changed everything, explained by someone who had one.
Heart valve replacement without open surgery, explained plainly.

What Is TAVR? Transcatheter Aortic Valve Replacement Explained End to End

Key takeaways

  • TAVR (transcatheter aortic valve replacement, also called TAVI) implants a new valve inside the diseased aortic valve using a catheter, without opening the chest or stopping the heart.
  • The catheter is usually threaded up the femoral artery in the groin, and the procedure is frequently done under conscious sedation rather than a general anaesthetic.
  • The old valve is not removed; the new tissue valve is expanded inside it and immediately takes over the job of opening and closing.
  • Hospital stay is typically 1 to 3 days, compared with about 5 to 7 days for open surgical replacement, and recovery is measured in weeks rather than months.
  • TAVR grew from the PARTNER and Evolut trials, which extended it from inoperable patients to high, then intermediate, then low surgical-risk patients, so it is now approved across the risk spectrum.
By Diane Farrow  |  Medically reviewed by Dr. Helena Voss, MD, FESC

Updated

TAVR, transcatheter aortic valve replacement, is a way of putting a new heart valve inside a worn-out one using a catheter, without opening the chest, without stopping the heart, and often without even putting you fully to sleep. When my cardiologist described it I thought I had misheard. What I expected was the sternum sawn open and weeks in hospital. What I was offered instead was a valve folded up small, threaded on a wire up through the artery in my groin, and opened inside the old one while my heart kept beating. This is the whole thing explained, start to finish.

What TAVR is

TAVR is the replacement of a narrowed aortic valve using a catheter, delivering a new valve to the heart through a blood vessel rather than through an opened chest. It is also called TAVI, transcatheter aortic valve implantation; the terms are interchangeable 1.

It treats aortic stenosis, the age-related narrowing of the aortic valve that stiffens it until the heart cannot push blood through properly. You can read the full picture of that condition in aortic stenosis explained. It is not a small problem to solve: once severe aortic stenosis starts causing symptoms, survival untreated is often quoted at around 50% at 2 years 2. The old fix was open-heart surgery. TAVR does the same essential job, swapping the failing valve, but reaches it from the inside, through the vascular system, which is why it counts as one of the largest shifts in heart medicine in decades 2.

How TAVR works

In TAVR a collapsed replacement valve is guided on a catheter up to the heart, positioned inside the diseased aortic valve, and then expanded so it takes over instantly. The new valve is mounted on a metal frame, or stent, and crimped down to a fraction of its final width so it fits inside the catheter 3.

Crucially, the old valve is not removed. The new valve is expanded inside it, pushing the diseased leaflets aside against the vessel wall, and the fresh valve immediately begins opening and closing with each heartbeat 2. There are two main designs. A balloon-expandable valve is pushed open by inflating a balloon inside it. A self-expanding valve is made of a metal that springs open to its full size once released from the catheter. Both are tissue valves, and like all tissue valves they are durable rather than permanent, showing good function to about 5 to 8 years in trials so far with longer-term data still maturing 4. The designs are discussed further in the types of heart valves.

How the valve gets to the heart

Most often the catheter is threaded up the femoral artery in the groin, a route called transfemoral access, and steered up to the heart. The femoral artery is large and close to the surface, which makes it the standard entry point 3. In my case a small puncture in the right groin was the only way in; there was no other cut.

When the leg arteries are too narrow or diseased, the team can use an alternative route, such as through an artery below the collarbone or a small cut between the ribs, but transfemoral is preferred wherever the anatomy allows 2. The journey the catheter makes up to the heart is also why the main serious risk is stroke, which occurs in roughly 2 to 3% of procedures 5. Whether your own arteries can take the transfemoral route is one of the things checked in advance, which is part of working out whether you are a candidate for TAVR.

Awake, not asleep: sedation in TAVR

TAVR is frequently done under conscious sedation, so you are relaxed and pain-free but not under a full general anaesthetic. This is one of the features that most surprises people. Because there is no chest incision and no need to control breathing for open surgery, many centres keep patients awake and lightly sedated 1.

I was awake for mine. I remember the calm voices of the team and the odd sensation of knowing something important was happening while feeling no pain at all. Some people still need a general anaesthetic depending on their situation and the centre’s approach, but the move towards conscious sedation is part of why the whole thing has become quicker and gentler, and part of why contemporary TAVR carries a 30-day mortality of only around 1 to 2% in lower-risk patients 5. A fuller account of the day is in what to expect during the TAVR procedure.

What recovery looks like

Recovery from TAVR is short compared with open surgery: hospital stay is typically 1 to 3 days, and normal life returns over weeks, not months. Because nothing in the chest has been cut, there is no breastbone to heal, which is the single biggest reason the recovery is so much faster 3. Open surgical replacement, by contrast, usually means about 5 to 7 days in hospital.

I went home after two nights. The main thing to look after early on is the small wound in the groin where the catheter went in. The detail of the timeline, the medication, and getting back to normal is covered in TAVR recovery. Like any cardiac procedure it carries risks, including stroke and the possible need for a pacemaker, set out honestly in TAVR risks and complications.

Why TAVR is a major advance

TAVR is considered a landmark advance because it made valve replacement possible for people who could never have survived open surgery, and then proved itself safe enough to offer far more widely. The evidence base is the PARTNER and Evolut trial programmes. They tested TAVR first in patients too frail or high-risk for an operation, then in intermediate-risk patients, and finally in low surgical-risk patients 5.

The low-risk trials were the turning point. In the PARTNER 3 trial of a balloon-expandable valve and the Evolut Low Risk trial of a self-expanding valve, TAVR performed at least as well as surgery for suitable patients on the key early outcomes 5 4. On the strength of that evidence, TAVR is now approved across the risk spectrum rather than reserved for the sickest, which is why a comparatively fit 74-year-old like me was offered it at all. Whether it is the right choice for a given person, and how it stacks up against an operation, is the subject of TAVR versus open-heart surgery, and the cost, which varies widely by country, is covered in how much TAVR costs.


General information, not medical advice. TAVR is not right for everyone, and whether it suits you is a decision for your own cardiologist and heart team, who can examine you, read your scans, and weigh your particular risks.

References

  1. TAVI (transcatheter aortic valve implantation), British Heart Foundation.
  2. Transcatheter aortic valve replacement (TAVR), Mayo Clinic.
  3. TAVR (Transcatheter Aortic Valve Replacement), Cleveland Clinic.
  4. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients (Evolut Low Risk), New England Journal of Medicine.
  5. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients (PARTNER 3), New England Journal of Medicine.

Common questions

What does TAVR stand for?

TAVR stands for transcatheter aortic valve replacement. In Europe the same procedure is usually called TAVI, transcatheter aortic valve implantation. The two terms mean the same thing: replacing a narrowed aortic valve using a catheter rather than open surgery.

Is TAVR major surgery?

Not in the way open-heart surgery is. There is no chest incision, the breastbone is not cut, the heart keeps beating throughout, and there is usually no heart-lung bypass machine. It is a catheter procedure done through a small puncture or cut in the groin, often under conscious sedation. It is still a serious cardiac procedure with real risks, but the recovery is far shorter than an operation.

How long does a TAVR procedure take?

The procedure itself is often around one to two hours, though the exact time varies with anatomy and the valve used. Because it is frequently done under conscious sedation rather than general anaesthetic, many people are awake, and the hospital stay afterwards is typically just 1 to 3 days.

Are you awake during TAVR?

Often, yes. Many centres now perform TAVR under conscious sedation, so you are relaxed and comfortable but not fully asleep, rather than under a general anaesthetic. I was awake for mine, aware of the team around me but feeling no pain. Some patients still have a general anaesthetic depending on their circumstances and the centre's practice.

Does TAVR remove the old valve?

No. Unlike open surgery, TAVR leaves the diseased valve in place and expands the new valve inside it, pushing the old leaflets aside against the wall. The new tissue valve immediately takes over the work of opening and closing with each heartbeat.

How long does recovery from TAVR take?

Much shorter than open surgery. Hospital stay is typically 1 to 3 days, and most people are back to their normal routine within a few weeks rather than the months a sternotomy can take. The main early restriction is looking after the groin access site while it heals.

Is TAVR permanent?

The valve is designed to last many years but is not permanent. TAVR uses a tissue (bioprosthetic) valve, and these wear out in time, showing good durability to about 5 to 8 years in trials, with longer-term data still maturing. If a TAVR valve eventually wears out, a second valve can often be placed inside it, a valve-in-valve procedure.

Written by Diane Farrow. Medically reviewed by Dr. Helena Voss, MD, FESC.

Our guides are written from personal experience and reviewed by a qualified clinician for accuracy. Read our editorial policy.

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Am I a Candidate for TAVR? The Heart Team, the CT Scan, and How the Decision Is Made · TAVR vs Open-Heart Surgery: Who Gets Which and What the Trials Showed · Types of Heart Valves: Tissue, Mechanical, and the TAVR Designs · TAVR Recovery: The Timeline From Discharge to Back to Normal · How Long Does a TAVR Valve Last? Durability and the Second Procedure