Musculoskeletal Disorder

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BREAKING NEWS: Editors’ Picks

Anti-CCP Test (Anti-Cyclic Citrullinated Peptide)

Anti-cyclic citrullinated peptide (anti-CCP) is an antibody present in most rheumatoid arthritis patients. Levels of anti-CCP can be detected in a patient through a blood test. A positive anti-CCP  test result can be used in conjunction with other blood tests, imaging tests, and physical examinations to reach a rheumatoid arthritis diagnosis.

Compound in green tea found to block rheumatoid arthritis. Arthritis Research & Therapy, 2016 Nov

A potential new approach to combating the joint pain, inflammation and tissue damage

Fibroblasts could provide new target for treatment of rheumatoid arthritis. Arthritis Research & Therapy, 2016 Nov

A new study reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints.

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. PNAS, 2016 Apr;

Arthritis and other inflammatory conditions could be helped by new insights into how the immune response is switched off. Scientists have discovered how compounds, called alpha defensins, produced by the body’s immune system help to dampen inflammation and prevent damage to healthy tissues.

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. JEM, October 6, 2015

Described how interleukin-27 regulates the inflammatory process in lymphoid-rich rheumatoid arthritis, suggesting that targeting this cytokine might be beneficial.

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. PNAS, August 31, 2015

Gene regulating severity of tissue damage caused by rheumatoid arthritis identified.