Org Lett. 2017 Feb 3;19(3):540-543. doi: 10.1021/acs.orglett.6b03708.

One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis.

Wang G, Chen J, Zhu H, Rohr J.
Harbor Branch Oceanographic Institute, Florida Atlantic University , 5600 US 1 North, Fort Pierce, Florida 34946, United States.

Abstract

Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (PKS) and early post-PKS enzymes from the biosynthetic pathways of three different types of type II-PKS driven anticancer antibiotics, namely, the mithramycin (aureolic acid-type), gilvocarcin (rearranged angucycline-type), and steffimycin (anthracycline) pathways.

PMID:28102686; DOI:10.1021/acs.orglett.6b03708

 

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